Journal of Hematology & Thromboembolic Diseases
Open Access

Graciana Souza Lordelo

Publications

• Review Article
  Role of Methylenetetrahydrofolate Reductase (Mthfr), Glutathione S-transferases (Gsts M1 and T1) and Haptoglobin (Hp) Gene Polymorphisms in Susceptibility to Chronic Myeloid Leukemia (Cml)
  Author(s): Ana Luisa Miranda-Vilela and Graciana Souza Lordelo Ana Luisa Miranda-Vilela and Graciana Souza Lordelo
  
  Chronic myeloid leukemia (CML) is a clonal myeloproliferative neoplasm derived from an abnormal pluripotent hematopoietic stem cell that underwent a chromosomal translocation t(9;22)(q34;q11) acquiring the BCR-ABL1 fusion gene, also known as the Philadelphia chromosome. Although the clinical and biological aspects are well documented, little is known about individual susceptibility to CML. There are no known hereditary, familial, geographic, ethnic, or economic associations with CML, and the mechanisms behind disease progression are not fully understood. However, while a specific chromosomal translocation is the common oncogenetic mechanism of CML, it may have environmental causes such as irradiation and chemical (e.g., benzene) exposure, which exert toxicity via pro-oxidant mechanisms. Oxidative stress has been observed in several hematopoietic malignancies, including acute and chronic .. View More»
  DOI: 10.4172/2329-8790.1000103

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