Journal of Depression and Anxiety
Open Access

Graham Emslie

Publications

• Research Article
  Ziprasidone in Pediatric Bipolar Disorder: A 6-Week, Open-Label Comparison of Rapid vs. Slow Dose Titration
  Author(s): Kirti Saxena, Annie Walley, Alex Simmons, Paul A. Nakonezny, Cintly Celis-deHoyos, Taryn Mayes, Cheryl L Person and Graham EmslieKirti Saxena, Annie Walley, Alex Simmons, Paul A. Nakonezny, Cintly Celis-deHoyos, Taryn Mayes, Cheryl L Person and Graham Emslie
  
    Objective: This open- label clinical trial evaluated the dosing, safety, and effectiveness of rapid vs. slow titration of ziprasidone in pediatric bipolar disorder over a period of 6 weeks. Methods: Study participants (aged 10-17 years) were diagnosed with bipolar disorder using standardized diagnostic instruments. Additionally, standardized rating scales were used to assess changes in mood, adverse effects, and overall functioning. Twenty-eight participants were randomly assigned to either the rapid- or slow-dose titration of ziprasidone. Linear mixed model analyses of repeated measures—adjusting for the age and respective baseline clinical score— were used to evaluate the main effects and the 2-way interaction effect (incorporating titration group and time). Cox Proportional Hazards Regression, adj.. View More»
  DOI: 10.4172/2167-1044.1000130

  Abstract PDF

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