Journal of Hematology & Thromboembolic Diseases
Open Access

Grandone Elvira

Publications

• Case Report
  Severe Thromboembolism and Systemic Lupus Erythematosus Developing after Ovarian Hyperstimulation in a Persistent Carrier of Antiphospholipid Antibodies
  Author(s): Grandone Elvira, Orefice Giuseppe, Jose Delgado Alves and Ames Paul RJGrandone Elvira, Orefice Giuseppe, Jose Delgado Alves and Ames Paul RJ
  
  Ovarian hyperstimulation (OH) is not a contraindication in selected women with antiphospholipid syndrome and/or systemic lupus erythematosus (SLE). A young woman who was persistently positive antiphospholipid antibodies, low protein free S and homozygous for the paraoxonase G192A mutation underwent three courses of OH; after the fourth course she developed severe thromboembolism and clinical features of SLE despite the use of a gonadotropin-releasing hormone agonist alongside aspirin that should have minimised the risk of OH syndrome. We provide a pathogenetic interpretation of these events in the light of the patient’s investigations... View More»
  DOI: 10.4172/2329-8790.1000150

  Abstract PDF

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