Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Gregory Lee
UBC Center for Reproductive Health,
Vancouver, British Columbia, V6P 6R9
Canada
Review Article
Cancerous Immunoglobulins in Cancer Immunology
Author(s): Gregory LeeGregory Lee
The expression of immunoglobulins by cancer cells have been known for two decades. However, the mechanisms of action behind these Cancerous Immunoglobulins (cIgG) are not well understood and may be different from immunoglobulins secreted by normal B lymphocytes. Therefore, the structural and functional roles of cIgG have been actively investigated to resolve this mystery. A monoclonal antibody, RP215, was generated in 1987 and was shown to react with a carbohydrate-associated epitope localized mainly on the heavy chains of cIgG but not on normal immunoglobulins. The knowledge of cIgG has been greatly advanced by using RP215 as a unique probe. Not only was RP215 shown to act as an anti-cIgG to induce apoptosis of cultured cancer cells in vitro/in vivo, it was also shown to elicit Complement-Dependent Cytotoxicity (CDC) reactions to trigger lysis of cancer c.. View More»
DOI:
10.4172/2155-9899.1000279