Pediatrics & Therapeutics
Open Access

Grzegorz Sowa

Publications

• Special Issue Article
  Role of Caveolin Proteins in Sepsis
  Author(s): Grzegorz SowaGrzegorz Sowa
  
  Despite the progress in medical treatment sepsis remains one of the major causes of death in pediatric and elderly patients. Understanding signaling pathways associated with sepsis may be of key significance for designing more efficient therapeutic approaches which could alleviate sepsis outcome. Earlier studies suggested that cholesteroland sphingolipid-rich lipid rafts and their morphologically distinct subset, caveolaecan be utilized by certain bacterial pathogens to enter and invade host cells. Moreover, there is also evidence that the expression levels of the major caveolar coat proteincaveolin-1 can be regulated by the major component of the outer membrane of Gram-negative bacteria,lipopolysaccharide (LPS) in various cell types involved in sepsis. In particular recent studies using caveolin-1 knockout mice and cells have revealed that caveolin-1 is d.. View More»
  DOI: 10.4172/2161-0665.S2-001

  Abstract PDF

Relevant Topics