Clinical & Experimental Cardiology
Open Access

Guillermo Villa

Publications

• Research Article
  Cardiovascular Disease and its Risk Factors in Patients with Familial Hypercholesterolemia: A Systematic Review
  Author(s): Gregory Kruse, Lucie Kutikova, Bruce Wong, Guillermo Villa, Kausik K Ray, Pedro Mata and Eric Bruckert Gregory Kruse, Lucie Kutikova, Bruce Wong, Guillermo Villa, Kausik K Ray, Pedro Mata and Eric Bruckert
  
  Objectives: Familial hypercholesterolemia (FH) leads to prolonged vascular exposure to high levels of lowdensity lipoprotein cholesterol and subsequent development of atherosclerotic lesions. This study examines additional risk factors in patients with FH and their impact on cardiovascular disease (CVD) risk. Methods: A systematic literature review identified publications describing cardiovascular risk in patients with FH (January-October 2016), extending a previous published review (2004-2015). Each article was assessed for bias by two reviewers using the modified Newcastle–Ottawa assessment scale for non-randomized studies. Additional risk factors studied included age, sex, FH mutations, and previous CVD. Results: Three new studies were identified, conducted in the Netherlands, Spain, and Brazil, and review.. View More»
  DOI: 10.4172/2155-9880.1000539

  Abstract PDF

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