Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Gunnur Deniz
Turkey
Research Article
Hyaluronan-Binding T Regulatory Cells in Peripheral Blood of Breast Cancer Patients
Author(s): Yuliya Perfilyeva, Yekaterina Ostapchuk, Esin Aktas Cetin, Abdullah Yilmaz, Gunnur Deniz, Shynar Talaeva, Nazgul Omarbaeva, Igor Oskolchenko and Nikolai BelyaevYuliya Perfilyeva, Yekaterina Ostapchuk, Esin Aktas Cetin, Abdullah Yilmaz, Gunnur Deniz, Shynar Talaeva, Nazgul Omarbaeva, Igor Oskolchenko and Nikolai Belyaev
Regulatory T cells (Treg), both natural and induced, play an important role in maintaining immune homeostasis. Alterations in the number and functions of Tregs are involved in tumor growth. One of the possible regulatory mechanisms of Treg functional activity involves interaction with major component of extracellular matrix hyaluronan. It has been demonstrated that high molecular weight hyaluronan promotes Treg function via increased expression of FoxP3 and production of IL-10. Moreover, previous research has shown highly enhanced suppressor function of hyaluronan-binding CD4+CD25+ Tregs in mice. Breast cancer is characterized by upregulated production of tumor-associated hyaluronan, therefore we investigated hyaluronan-binding subset of Tregs obtained from peripheral blood of breast cancer patient.. View More»
DOI:
10.4172/2155-9899.1000286