Journal of Clinical and Cellular Immunology

Journal of Clinical and Cellular Immunology
Open Access

ISSN: 2155-9899

+44 1223 790975

Gunnur Deniz

Gunnur Deniz

Turkey

Publications
  • Research Article
    Hyaluronan-Binding T Regulatory Cells in Peripheral Blood of Breast Cancer Patients
    Author(s): Yuliya Perfilyeva, Yekaterina Ostapchuk, Esin Aktas Cetin, Abdullah Yilmaz, Gunnur Deniz, Shynar Talaeva, Nazgul Omarbaeva, Igor Oskolchenko and Nikolai BelyaevYuliya Perfilyeva, Yekaterina Ostapchuk, Esin Aktas Cetin, Abdullah Yilmaz, Gunnur Deniz, Shynar Talaeva, Nazgul Omarbaeva, Igor Oskolchenko and Nikolai Belyaev

    Regulatory T cells (Treg), both natural and induced, play an important role in maintaining immune homeostasis. Alterations in the number and functions of Tregs are involved in tumor growth. One of the possible regulatory mechanisms of Treg functional activity involves interaction with major component of extracellular matrix hyaluronan. It has been demonstrated that high molecular weight hyaluronan promotes Treg function via increased expression of FoxP3 and production of IL-10. Moreover, previous research has shown highly enhanced suppressor function of hyaluronan-binding CD4+CD25+ Tregs in mice. Breast cancer is characterized by upregulated production of tumor-associated hyaluronan, therefore we investigated hyaluronan-binding subset of Tregs obtained from peripheral blood of breast cancer patient.. View More»
    DOI: 10.4172/2155-9899.1000286

    Abstract PDF

Relevant Topics

Top