Immunome Research
Open Access

Gustavo Fretchtel

Publications

• Case Report
  Acetyl-L-Carnitine and Nicotinamide for Prevention of Type 1 Diabetes. I-Literature Review which Gave Support to the Treatment. II-Case Report, Evaluation of Five Years Treatment
  Author(s): Ivana Fernandez, Miriam Tonietti, Maria del Carmen Camberos, Ignacio Bergada, Andrea Schenone, Marina Szlago, Mariana Tellechea, Gustavo Fretchtel, Liliana Trifone and Juan Carlos Cresto Ivana Fernandez, Miriam Tonietti, Maria del Carmen Camberos, Ignacio Bergada, Andrea Schenone, Marina Szlago, Mariana Tellechea, Gustavo Fretchtel, Liliana Trifone and Juan Carlos Cresto
  
  In the first part, this article review the accepted knowledge of type 1 diabetes, its physiopathology, the importance of cytokines and the induction of apoptosis and necrosis during its evolution. Throughout this work we describe in more detail the inhibition of this mechanism of cell destruction by acetyl-L-carnitine and nicotinamide. We also explain the complementary action of their association which gave support to the treatment. In the second part, we present the complete evolution of 8 children treated with the oral medication of 50 mg/Kg of acetyl-L-carnitine plus 25 mg/Kg of nicotinamide during 5 years. We published the first 2 years of evolution under treatment in these children (JPEM 26: 347, 2013). The children had positive auto-antibodies and were consanguineous of type 1 diabetic patients. The intravenous glucose tolerance test (IVGTT) showed a first phase of insulin relea.. View More»
  DOI: 10.4172/1745-7580.1000094

  Abstract PDF

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