Anatomy & Physiology: Current Research
Open Access

Hagar A Hashish

Publications

• Research Article
  Alteration of Glial Fibrillary Acidic Protein Immunoreactivity in Astrocytes of the Cerebellum of Diabetic Rats and Potential Effect of Insulin and Ginger
  Author(s): Hagar A Hashish Hagar A Hashish
  
  Background: Diabetes causes increased oxidative stress and changes in vascular reactivity in the brain. Ginger has a wide range of pharmacological properties including anti-inflammatory, anti-microbial, antioxidant, and antitumour effects. Aim of the work: The purpose of this study was to clarify the effect of induced type I diabetes on the cerebellum of albino rat and whether these changes could be prevented by insulin and ginger. Material and methods: Forty albino rats were divided randomly into 4 groups; control non-diabetic rats; untreated diabetic rats; insulin-treated diabetic rats and combined insulin-ginger treated diabetic rats. After 8 weeks of treatment, animals were sacrificed; cerebellum was dissected, processed and stained with H&E and immunohistochemistry for Glial Fibrillary Acidic Protein (GFAP). Results: Diabetes caused decrease .. View More»
  DOI: 10.4172/2161-0940.1000167

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