Journal of Clinical & Experimental Dermatology Research
Open Access
ISSN: 2155-9554
+44 1478 350008
ISSN: 2155-9554
+44 1478 350008
Research Article
Effects of Oral Antioxidants on Lesion Counts Associated with Oxidative Stress and Inflammation in Patients with Papulopustular Acne
Author(s): Ahmed Salih Sahib, Haidar Hamid Al-Anbari, Mohammed Salih and Fatima AbdullahAhmed Salih Sahib, Haidar Hamid Al-Anbari, Mohammed Salih and Fatima Abdullah
Background: There has been an increasing focus on the extent to which oxidative stress and inflammation are involved in the pathophysiology of acne. The aim of this study is to investigate the effect of oral Silymarin, N-acetylcysteine and Selenium in the treatment of acne vulgaris. Methods: A randomized prospective clinical trial was carried out on 56 patients with acne vulgaris who were examined clinically by dermatologist and classified according to disease severity. Serum levels of Glutathione, Malondialdehyde and Interleukine-8 in the acne patients were measured pre- and eight weeks post-treatment with oral antioxidants and compared to that of 28 healthy volunteers. The clinical follow- up was done every two weeks to assess the changes in the number of inflammatory lesions. Results: Administration of antioxidants to p.. View More»
DOI:
10.4172/2155-9554.1000163