Journal of Chromatography & Separation Techniques
Open Access

Haiyan Liu

Publications

• Research Article
  Preparation of a Novel Emulsion-Templated MIP Monolith and its Application for on Line Assay of Nifedipine in Human Plasma
  Author(s): Gengliang Yang, Yankun Liu, Haiyan Liu, Chunliu Yang, Ligai Bai, Mingquan Liu and Jia Cheng Gengliang Yang, Yankun Liu, Haiyan Liu, Chunliu Yang, Ligai Bai, Mingquan Liu and Jia Cheng
  
  A novel nifedipine molecularly imprinted polymer (MIP) monolith was prepared by radical polymerization of the water in oil (W/O) emulsions, using vinyl ester resin and methacrylic acid (MAA) as the monomers and nonionic surfactants such as Polyethylene glycol 400 (PEG 400) and Pluronic F68 (PF 68) as the emulsifying agents. The properties of the material were investigated. The MIP monolithic column was installed in the high performance liquid chromatography (HPLC) system and used as the selective sorbent for on line solid-phase extraction of nifedipine in human plasma due to the good selectivity to nifedipine. For this method, the calibration curve was linear in the concentration range of 5-150 ng/mL (r2=0.998) for nifedipine in human plasma and the limit of detection (LOD) was 2 ng/mL. Accuracy, precisions and recovery was acceptable for screening nifedipine in plasma samples. The re.. View More»
  DOI: 10.4172/2157-7064.1000103

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