Organic Chemistry: Current Research
Open Access

Hamada S Abulkhair

Publications

• Research Article
  Synthesis, Characterization and In Vitro Antitumor Evaluation of New Pyrazolo[3,4-d]Pyrimidine Derivatives
  Author(s): Ahmed M El-Morsy, Mohamed S El-Sayed, Hamada S Abulkhair Ahmed M El-Morsy, Mohamed S El-Sayed, Hamada S Abulkhair
  
  A new series of 3-(methylthio)-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine derivatives was synthesized. The antitumor activity of this series against human breast adenocarcinoma cell line MCF7 was evaluated. Out of twenty new derivatives, ten were revealed mild to moderate activity compared with doxorubicin as a reference antitumor. Among this new series N-(2-chlorophenyl)-2-(3-(methylthio)-4-oxo-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-5(4H)-yl)acetamide (13 a) was found the most active one with IC50 equal to µM. .. View More»
  DOI: 10.4172/2161-0401.1000176

  Abstract PDF

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