Chemotherapy: Open Access
Open Access

Han Y

Publications

• Research Article
  The Association between the C1772T Genetic Polymorphism in Human HIF-1α Gene and Breast Cancer Risk: A Meta-analysis
  Author(s): Cheng K, Yuan Shen Y, Liu J, Wang XH, Hua YI, Jia ZM, Han Y, Sun HG and Yang ZL Cheng K, Yuan Shen Y, Liu J, Wang XH, Hua YI, Jia ZM, Han Y, Sun HG and Yang ZL
  
  Purpose: This meta-analysis aims to investigate the association between the C1772T genetic polymorphism in human HIF-1α gene and breast cancer risk. Methods: PubMed and Embase databases were searched till October 2013 to identify eligible studies. A total of 2143 cases and 2046 controls from 6 studies were included in this paper. Allelic and genotypic comparisons between cases and controls were evaluated. Subgroup analyses by ethnicity were also performed. Results: The recessive model, dominant model, comparison suggested that the genotype C1772T polymorphism was not significant without the increased breast risk: OR=1.38 [95% CI (0.35, 5.46)], P=0.65 and OR=1.14 [95% CI (0.83, 1.55)], P=0.43, respectively. The results for the co-dominant model comparison were not different with the results as follows: OR=1.. View More»
  DOI: 10.4172/2167-7700.1000243

  Abstract PDF

Relevant Topics