Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Hana A Sadek
Egypt
Research Article
Anti-Mutated Citrullinated Vimentin (Anti-MCV) Antibodies as a Diagnostic Aid for Rheumatoid Arthritis
Author(s): Khaled S Osman, Lamiaa H Aly, Ahmed A Saedii, Huda T Abbas and Hana A SadekKhaled S Osman, Lamiaa H Aly, Ahmed A Saedii, Huda T Abbas and Hana A Sadek
Background: This study aimed to evaluate the role of anti-MCV antibodies in the diagnosis of RA and correlate anti-MCV with other markers of disease activity. Subjects and methods: The study was carried out on 70 individuals, categorized as follows; 40 patients diagnosed as rheumatoid arthritis (RA) (Group I), 15 patients diagnosed as osteoarthritis disease (OA) (Group II) and their results were compared to 15 apparently healthy persons as control group (Group III). All participants were subjected to careful history taking, general examination, routine laboratory investigations, in addition to, anti-cyclic citrullinated peptide (anti-CCP) and anti-mutated citrullinated vimentin (anti-MCV) assays. Results: Anti-CCP and anti-MCV values were significantly higher in group I when compared to group II and III (Pvalue<0.001 .. View More»
DOI:
10.4172/2155-9899.1000263