Journal of Alcoholism & Drug Dependence
Open Access
ISSN: 2329-6488
ISSN: 2329-6488
Harinder Aujla
Winnipeg
Canada
Review Article
Assessing Anxiety and Reward-Related Behaviors Following Alcohol Administration or Chronic Stress
Author(s): Harinder Aujla, Craig Hutton and Benjamin RogalaHarinder Aujla, Craig Hutton and Benjamin Rogala
Dysregulation of stress- and reward-related neurocircuitry that results from experience with alcohol or chronic stress may underlie vulnerability to initiate or relapse to alcohol use. Related changes in behaviors associated with such dysregulation may provide insight into factors that increase or decrease vulnerability to alcohol dependence in humans. In the present study, anxiety-like behavior and the acquisition of conditioned place preference were assessed in male Wistar rats with differing histories of exposure to stress or alcohol two weeks following the termination of treatment. Thus, time spent on the open arms of the elevated plus maze as well as the number of days required to acquire alcohol-based place conditioning were evaluated in control animals vs. those with a history of exposure to chronic unpredictable stress, experimenter-administered intragastric alcohol, or selfad.. View More»
DOI:
10.4172/2329-6488.1000136