Journal of Proteomics & Bioinformatics
Open Access

Heather M. Brewer

Publications

• Research Article
  Proteome of Salmonella Enterica Serotype Typhimurium Grown in a Low Mg²⁺/pH Medium
  Author(s): Liang Shi, Charles Ansong, Heather Smallwood, Leah Rommereim, Jason E. McDermott, Heather M. Brewer, Angela D. Norbeck, Ronald C. Taylor, Jean K. Gustin, Fred Heffron, Richard D. Smith and Joshua N. Adkins Liang Shi, Charles Ansong, Heather Smallwood, Leah Rommereim, Jason E. McDermott, Heather M. Brewer, Angela D. Norbeck, Ronald C. Taylor, Jean K. Gustin, Fred Heffron, Richard D. Smith and Joshua N. Adkins
  
  To determine the impact of a low Mg2+/pH defined growth medium (MgM) on the proteome of Salmonella enterica serotype Typhimurium, we cultured S. Typhimurium cells in the medium under two different conditions termed MgM Shock and MgM Dilution and then comparatively analyzed the bacterial cells harvested from these conditions by a global proteomic approach. Proteomic results showed that MgM Shock and MgM Dilution differentially affected the S. Typhimurium proteome. MgM Shock induced a group of proteins whose induction usually occurred at low O2 level, while MgM Dilution induced those related to the type III secretion system (T3SS) of Salmonella Pathogenicity Island 2 (SPI2) and those involved in thiamine or biotin biosynthesis. The metabolic state of the S. Typhimurium cells grown under MgM Shock condition also differed significantly from that under MgM Dilution conditi.. View More»
  DOI: 10.4172/jpb.1000099

  Abstract PDF

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