Journal of Drug Metabolism & Toxicology
Open Access

Heba Hassan Elsedfy

Publications

• Research Article
  Hazardous Influence of Hydroxyurea on Spermatogenesis in Thalassemia Intermedia Patients: An Egyptian Cohort Study
  Author(s): Mohsen Saleh Elalfy, Fatma Soliman Elsayed Ebeid*, Islam Reda Elgamry, Ghada Mamdouh Fawzy,Heba Hassan Elsedfy, Mohamed Tarif HamzaMohsen Saleh Elalfy, Fatma Soliman Elsayed Ebeid*, Islam Reda Elgamry, Ghada Mamdouh Fawzy,Heba Hassan Elsedfy, Mohamed Tarif Hamza
  
  Background: Hydroxyurea (HU), frequently used in thalassemia intermedia (TI), might have adverse effects on spermatogenesis. Aim: To assess the effects of HU treatment on sperm parameters and potential reversibility on its discontinuation in TI patients. Methods: Twenty fully-pubertal male TI patients regularly followed-up at the Ain Shams University Thalassemia Center were classified according to previous HU treatment (1:1); first group had received HU for ≥ one year, while the second had never received HU. All recruited patients were subjected to full clinical assessments. Sperm parameters (number, abnormal forms, motility and forward progression) were assessed at enrollment and reassessed six- months after stopping HU treatment. Result: Eleven patients on HU therapy had statistically significant lower sperm count in comparison to those who had never received HU. At si.. View More»
  DOI: 10.4172/2157-7609.1000237

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