Journal of Research and Development
Open Access

Heena Patel

Publications

• Research Article
  Changes in Plasma Levels of Asymmetric Dimethylarginine in Chronic Kidney Disease Patients Treated for 8 Weeks with the Vitamin D Receptor Agonist Paricalcitol
  Author(s): Amy Barton Pai1, Darren W Grabe, George Eisele, Syed Haqqie, Heena Patel, Alexander J Prokopienko, Thomas D Nolin, Natsuki Kubotera Amy Barton Pai1, Darren W Grabe, George Eisele, Syed Haqqie, Heena Patel, Alexander J Prokopienko, Thomas D Nolin, Natsuki Kubotera
  
  Objective: We investigated the effect of the vitamin D receptor agonist (VDRA), paricalcitol on biomarkers of endothelial dysfunction in patients with chronic kidney disease (CKD). Methods: This was an 8-week, randomized, blinded, controlled trial of paricalcitol versus placebo in 40 CKD patients. Serum chemistry, asymmetric dimethyl arginine (ADMA), soluble intracellular adhesion molecule (ICAM), vascular adhesion molecule (VCAM), biomarkers of vascular reactivity (Regulated on activation, normal T cell expressed and secreted (RANTES), vascular endothelial growth factor (VEGF), monocyte chemoattractant protein (MCP-1)) and pro-inflammatory cytokines (interleukin-1(IL-1) interleukin (IL-6), tumor necrosis factor- (TNF)) at baseline, week 4 and week 8. Resul.. View More»
  

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