Journal of Clinical and Cellular Immunology
Open Access

Hendrick Pagan

Publications

• Short Communication
  The Probiotic Mixture VSL#3 Alters the Morphology and Secretion Profile of Both Polarized and Unpolarized Human Macrophages in a Polarization-Dependent Manner
  Author(s): Raymond A. Isidro, Fernando J. Bonilla, Hendrick Pagan, Myrella L. Cruz, Pablo Lopez, Lenin Godoy, Siomara Hernández, Raisa Y. Loucil-Alicea, Vanessa Rivera-Amill, Yasuhiro Yamamura, Angel A. Isidro and Caroline B. AppleyardRaymond A. Isidro, Fernando J. Bonilla, Hendrick Pagan, Myrella L. Cruz, Pablo Lopez, Lenin Godoy, Siomara Hernández, Raisa Y. Loucil-Alicea, Vanessa Rivera-Amill, Yasuhiro Yamamura, Angel A. Isidro and Caroline B. Appleyard
  
  Background: Patients with Inflammatory Bowel Disease (IBD), most commonly Crohn’s disease (CD) or ulcerative colitis (UC), suffer from chronic intestinal inflammation of unknown etiology. Increased proinflammatory macrophages (M1) have been documented in tissue from patients with CD. Anti-inflammatory macrophages (M2) may play a role in UC given the preponderance of Th2 cytokines in this variant of IBD. Animal and clinical studies have shown that the probiotic VSL#3 can ameliorate signs and symptoms of IBD. Although animal data suggests a modulatory effect on macrophage phenotype, the effect of VSL#3 on human macrophages remains unknown.Objective: To determine the effect of the probiotic VSL#3 on the phenotype of polarized (M1/M2) and unpolarized (MΦ) human macrophages.Methods: Human monocyte-derived macrophages.. View More»
  DOI: 10.4172/2155-9899.1000227

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