Journal of Hematology & Thromboembolic Diseases
Open Access
ISSN: 2329-8790
+44 1478 350008
ISSN: 2329-8790
+44 1478 350008
Hendrik De Raeve
Belgium
Research Article
The 2006 2008 European Clinical, Molecular and Patholobiogical (2008 ECMP) Classification and the 2007 WHO Revised Criteria for Myeloproliferative Neoplasms
Author(s): Jan J Michiels, Zwi Berneman, Wilfried Schroyens, Konnie Hebeda, King H Lam, Francisca Valster, Vincent Potter, Katrien Schelfout, Hendrik De RaeveJan J Michiels, Zwi Berneman, Wilfried Schroyens, Konnie Hebeda, King H Lam, Francisca Valster, Vincent Potter, Katrien Schelfout, Hendrik De Raeve
The classifications of Myeloproliferative Disorders (MPD) by the Polycythemia Vera Study Group (PVSG) and World Health Organization (WHO) used crude criteria for the diagnoses of Essential Thrombocythemia (ET), Polycythemia Vera (PV) and Primary Myelo Fibrosis (PMF). The PVSG and the 2007 WHO criteria for the diagnosis of ET and PVoverlook the very early prefibrotic stages of MPN. The 2008 European Clinical, Molecular and Pathological (2008 ECMP) criteria are sensitive for the detection of early stages of JAK2V617F trilinear Myelo Proliferative Neoplasms (MPN) and could delineate three stages JAK2V617F mutated ET: normocellular ET; ET with features of early PV (prodromal PV); and ET with Hypercellular Megakaryocytic Granulocytic Myeloproliferation (EMGM). The 2008 ECMP classification distinguishes six clinical PV stages that have important prognostic and therapeutic implications. Spon.. View More»
DOI:
10.4172/2329-8790.1000190