Anesthesia & Clinical Research
Open Access

Henrik Kehlet

Publications

• Research Article
  High-Volume Infiltration Analgesia in Major Lumbar Spine Surgery. A Randomized, Placebo-Controlled, Double-Blind Trial
  Author(s): Billy B Kristensen, Hikmet Karacan, Marianne Agerlin, Lars Nimb, James Stentoft, Jon Tuxøe and Henrik KehletBilly B Kristensen, Hikmet Karacan, Marianne Agerlin, Lars Nimb, James Stentoft, Jon Tuxøe and Henrik Kehlet
  
  Background: High-volume local infiltration analgesia is effective in knee arthroplasty, but the analgesic efficacy of systematic infiltration with high-volume local anesthetic in major lumbar spine surgery in L3 to S1 has not been clarified. We conducted a trial to evaluate the analgesic efficacy of intraoperative Local Infiltration Analgesia (LIA) administration and postoperatively via injections through intraoperatively placed wound catheters. Methods: In a randomized, double-blind, placebo-controlled trial in 48 patients undergoing major lumbar spine fusion surgery, 70 mL saline (n=24) or ropivacaine 0.5% with adrenaline (n=24) was infiltrated using a systematic technique to all tissue incised, handled or instrumented during surgery and with repeated injections at 6, 12 and 24 h postoperatively with 10, 10 and 20 mL. Twenty-two patients in .. View More»
  DOI: 10.4172/2155-6148.1000450

  Abstract PDF

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