Journal of Clinical & Experimental Dermatology Research
Open Access

Herbert B. Allen

Publications

• Commentary
  The Role of Propionibacterium acnes Biofilm in Acne Vulgaris
  Author(s): Anthony Linfante, Rina M. Allawh and Herbert B. AllenAnthony Linfante, Rina M. Allawh and Herbert B. Allen
  
  Acne vulgaris is traditionally known as the result of excess sebum production, follicular hyper keratinization, infection with Propionibacterium acnes, and follicular inflammation. However, the role of P. acnes is gaining momentum as the primary impetus in the pathogenesis of acne vulgaris. The biofilm-forming ability of P. acnes in vitro and on indwelling medical appliances and catheters has been known for quite some time, but only in the last decade has the presence of P. acnes biofilm been observed within the pilosebaceous unit. Since that time, the genome of the microbe has been sequenced, and genes responsible for quorum sensing and biofilm formation have been confirmed. As a result of biofilm formation, the virulence of P. acnes is amplified. Biofilm-encapsulated P. acnes upregulates the production of lipases, resulting in the production of free fatty acids. Free fatty acids as .. View More»
  DOI: 10.4172/2155-9554.1000439

  Abstract PDF

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