Journal of Developing Drugs

Journal of Developing Drugs
Open Access

ISSN: 2329-6631

+44 1478 350008

Himankar Baishya

Himankar Baishya
North Shi Zhen in the North Industrial area,
Shunyi District, Beijing
China

Publications
  • Research Article
    Application of Mathematical Models in Drug Release Kinetics of Carbidopa and Levodopa ER Tablets
    Author(s): Himankar BaishyaHimankar Baishya

    The aim of present work is to determine and analyse the kinetics of drug release from the matrix tablet by employing various mathematical models. A study was done with Carbidopa and Levodopa ER tablets, 50 mg/200 mg by employing wet granulation technique using Hydroxypropyl methylcellulose and Hydroxypropyl cellulose as matrix forming polymer. The in-vitro drug release profile was carried out in 0.1 N HCl (900 mL) using USP dissolution apparatus II (Paddle) at 50 rpm at an extended time period of 0.5, 0.75, 1, 1.5, 2, 2.5, 3 and 4 hours. The drug release data was obtained, quantitatively correlated and interpreted with various mathematical models viz. Zero order model, first order model, Higuchi model, Hixson-Crowell model and Korsmeyer-Peppas model and evaluated to understand the kinetics of drug release. The criterion for the most suitable model was based on the high degree of coeff.. View More»
    DOI: 10.4172/2329-6631.1000171

    Abstract PDF

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