Clinical & Experimental Cardiology
Open Access

Himanshu Gupta

Publications

• Research Article
  HDL Mimetic Peptide Administration Improves Left Ventricular Filling and Cardiac output in Lipopolysaccharide-Treated Rats
  Author(s): Geeta Datta, Himanshu Gupta, Zhenghao Zhang, Palgunachari Mayakonda, G.M. Anantharamaiah and C. Roger White Geeta Datta, Himanshu Gupta, Zhenghao Zhang, Palgunachari Mayakonda, G.M. Anantharamaiah and C. Roger White
  
  Aims: Cardiac dysfunction is a complication of sepsis and contributes to morbidity and mortality. Since raising plasma apolipoprotein (apo) A-I and high density lipoprotein (HDL) concentration reduces sepsis complications, we tested the hypothesis that the apoA-I mimetic peptide 4F confers similar protective effects in rats treated with lipopolysaccharide (LPS). Methods and results: Male Sprague-Dawley (SD) rats were randomized to receive saline vehicle (n=13), LPS (10 mg/kg: n=16) or LPS plus 4F (10 mg/kg each: n=13) by intraperitoneal injection. Plasma cytokine and chemokine levels were significantly elevated 24 hrs after LPS administration. Echocardiographic studies revealed changes in cardiac dimensions that resulted in a reduction in left ventricular end-diastolic volume (LVEDV), stroke volume (SV) and cardiac output (CO) 24 hrs after LPS administration. 4F treatment reduced plas.. View More»
  DOI: 10.4172/2155-9880.1000172

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