Chemotherapy: Open Access
Open Access

Hiroaki Hasegawa

Publications

• Research Article
  Therapeutic Efficacy and Dosage of Pazopanib for Metastatic or Unresectable Advanced Soft Tissue Sarcomas
  Author(s): Hideshi Sugiura, Yoshihiro Nishida, Masahiro Yoshida, Hiroaki Hasegawa, Kenji Yamada, Yoshihisa Yamada and Masashi Ando Hideshi Sugiura, Yoshihiro Nishida, Masahiro Yoshida, Hiroaki Hasegawa, Kenji Yamada, Yoshihisa Yamada and Masashi Ando
  
  Abstract Objective: The molecular targeted drug pazopanib is a selective oral tyrosine kinase inhibitor that exerts its effects on vascular endothelial growth factor receptors (VEGF-R) and inhibits angiogenesis. This study aimed to examine the therapeutic efficacy, incidence of adverse events (AEs), and dosage of pazopanib in Japanese patients with metastatic or unresectable advanced soft tissue sarcoma. Methods: Subjects were 42 patients (16 men and 26 women) with a history of previous anti-cancer agent treatment, who were administered pazopanib for metastatic or unresectable soft tissue sarcoma between November 2012 and August 2014 at our hospital or affiliated hospitals. Pazopanib was administered at an initial dose of 800 mg/day in 25 patients, 600 mg/day in 7 patients, and 400 mg/day in 10 patients; dose was reduced by 200 mg when continuation of treatment was deemed difficult due t.. View More»
  DOI: 10.4172/2167-7700.1000144

  Abstract PDF

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