Journal of Alcoholism & Drug Dependence
Open Access

Hirotaka Takizawa

Publications

• Research Article
  Determination of Serum Carbohydrate-Deficient Transferrin (CDT) by the Nephelometric N Latex CDT Assay in Japanese Habitual Drinkers and Patients with Non-Alcoholic Liver Diseases
  
  Author(s): Mako Yamada, Masanori Seimiya, Mamoru Satoh, Sakae Itoga, Kazuyuki Sogawa, Hirotaka Takizawa, Osamu Yokosuka BD and Fumio NomuraMako Yamada, Masanori Seimiya, Mamoru Satoh, Sakae Itoga, Kazuyuki Sogawa, Hirotaka Takizawa, Osamu Yokosuka BD and Fumio Nomura
  
  Background: Excessive alcohol consumption is a health risk that can lead to a variety of medical and social problems. Carbohydrate Deficient Transferrin (CDT) is now widely used for detection of chronic alcohol abuse and monitoring sobriety in alcoholics. We assessed the diagnostic performance of the direct immunoassay for %CDT (N Latex CDT) in Japanese habitual drinkers at their annual medical check-up. We also tested whether this direct assay is influenced by the presence of non-alcoholic liver disease including non-alcoholic steatohepatitis and HCVrelated hepatocellular carcinoma. Methods: We performed the N Latex CDT assay using a Siemens BN-II nephelometric analyzer to measure CDT concentration. The reference intervals of %CDT and gamma glutamyl transferase (GGT) activities were obtained based on their measurements in 160 apparently healt.. View More»
  DOI: 10.4172/2329-6488.1000138

  Abstract

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