Journal of Clinical & Experimental Dermatology Research
Open Access

Hiroyuki Murota

Publications

• Review Article
  Platelet Activation as a Possible Indicator of Disease Activity in Chronic Urticaria: Link with Blood Coagulation and Mast Cell Degranulation
  Author(s): Ichiro Katayama, Saki Matsui and Hiroyuki Murota Ichiro Katayama, Saki Matsui and Hiroyuki Murota
  
  Background: Much attention has been paid to activation of the blood coagulation cascade during urticaria attacks. Elevated levels of plasma D-dimer and prothrombin fragment 1+2 have been reported. The final product of the coagulation cascade, thrombin, may induce mast cell degranulation, complement fragmentation, or platelet-activating factor expression. However, the involvement of platelets in urticaria is poorly understood. Methods: We examined the relationship between disease activity and plasma levels of platelet factor IV, β-thromboglobulin, D-dimer, and prothrombinfragment (Fr) 1+2 in 23 patients with chronic urticaria. Results: We observed elevated plasma levels of platelet factor IV (13/23) and β-thromboglobulin (15/23) in patients with chronic urticaria that returned to normal after anti-histamine th.. View More»
  DOI: 10.4172/2155-9554.1000194

  Abstract PDF

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