Endocrinology & Metabolic Syndrome
Open Access

Hisaya Kawate

Publications

• Research Article
  Cytochrome P450 1A2 Polymorphisms, Coffee Consumption and Impaired Glucose Metabolism in Japanese Men
  Author(s): Michiko Kohno, Osamu Tajima, Kousaku Uezono, Shinji Tabata, Hiroshi Abe, Masahiro Adachi, Hisaya Kawate, Keizo Ohnaka, Masatoshi Nomura, Suminori Kono and Ryoichi TakayanagiMichiko Kohno, Osamu Tajima, Kousaku Uezono, Shinji Tabata, Hiroshi Abe, Masahiro Adachi, Hisaya Kawate, Keizo Ohnaka, Masatoshi Nomura, Suminori Kono and Ryoichi Takayanagi
  
  Objective: Coffee consumption has been related to decreased risk of type 2 diabetes, but it is unclear whether this relation is affected by cytochrome P450 1A2 (CYP1A2), a primary enzyme of caffeine metabolism. We examined the associations of two functional genetic polymorphisms of CYP1A2 with glucose tolerance status and the effect modification of the CYP1A2 polymorphisms on the association between coffee and impaired glucose metabolism. Methods: The subjects were 2263 male officials aged 46-59 years in the Self-Defense Forces in Japan. Individual glucose tolerance status was classified into normal glucose tolerance, Impaired Fasting Glycemia (IFG), Impaired Glucose Tolerance (IGT) or type 2 diabetes by a 75 g oral glucose tolerance test. IFG and IGT were combined as a single entity (IFG/IGT). Coffee consumption was assessed by a sel.. View More»
  DOI: 10.4172/2161-1017.1000119

  Abstract PDF

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