ISSN: 2379-1764
+44 1223 790975
Huafang Lai
Tanzania
Review Article
Agroinfiltration as an Effective and Scalable Strategy of Gene Delivery for Production of Pharmaceutical Proteins
Author(s): Qiang Chen, Huafang Lai, Jonathan Hurtado, Jake Stahnke, Kahlin Leuzinger and Matthew DentQiang Chen, Huafang Lai, Jonathan Hurtado, Jake Stahnke, Kahlin Leuzinger and Matthew Dent
Current human biologics are most commonly produced by mammalian cell culture-based fermentation technologies. However, its limited scalability and high cost prevent this platform from meeting the ever increasing global demand. Plants offer a novel alternative system for the production of pharmaceutical proteins that is more scalable, cost-effective, and safer than current expression paradigms. The recent development of deconstructed virus-based vectors has allowed rapid and high-level transient expression of recombinant proteins, and in turn, provided a preferred plant based production platform. One of the remaining challenges for the commercial application of this platform was the lack of a scalable technology to deliver the transgene into plant cells. Therefore, this review focuses on the development of an effective and scalable technology for gene delivery in plant.. View More»
DOI:
10.4172/2379-1764.1000103