Journal of Clinical Trials
Open Access

Hughes Andrew J

Publications

• Editorial Comment
  Randomized Controlled Trial of Short Course Intravenous Therapy for Cellulitis and Erysipelas of the Lower Limb (Switch): Study Protocol and Pilot Trial Results
  Author(s): Deborah N Friedman, Pollard James, Huffam Sarah, Walton Aaron L, O’Brien Daniel P, Cowan Raquel U, Lim Karen, Lane Stephen E, Sarah Alana J, Chambers Jo, Gay Caroline L, Simpson Paul E, Hughes Andrew J and Athan Eugene Deborah N Friedman, Pollard James, Huffam Sarah, Walton Aaron L, O’Brien Daniel P, Cowan Raquel U, Lim Karen, Lane Stephen E, Sarah Alana J, Chambers Jo, Gay Caroline L, Simpson Paul E, Hughes Andrew J and Athan Eugene
  
  Study background: Cellulitis and erysipelas are common skin and soft tissue infections. Antibiotics are the mainstay of therapy, but to date there is no consensus on whether intravenous or oral therapy are optimal choices, and the suggested duration of therapy. Methods: In a randomized non-inferiority, parallel trial, consecutive eligible adult patients will be randomized by random block allocation to the intervention arm of 24 hours IV therapy versus ≥ 72 hours IV therapy (both followed by oral therapy to total duration of 10 days). Antibiotics used are anti-staphylococcal penicillins and first generation cephalosporins. Resolution of cellulitis is defined by; resolution of fever, lack of progression of the involved area at 48-72 hours, and lack of requirement for antibiotics beyond the study period of 10 days. Secondary outcome measures include; pain in the a.. View More»
  DOI: 10.4172/2167-0870.1000200

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