Organic Chemistry: Current Research
Open Access

Hyacinthe F. Agnimonhan

Publications

• Research Article
  Willgerodt-Kindler Reaction’s Microwave-Enhanced Synthesis of Thiobenzamides Derivatives in Heterogeneous Acid Catalysis with Montmorillonite K-10
  Author(s): Hyacinthe F. Agnimonhan, Léon A. Ahoussi, Bienvenu Glinma, Justin M. Kohoudé, Fernand A. Gbaguidi, Salomé D. S. Kpoviessi, Jacques Poupaert and Georges C. Accrombessi Hyacinthe F. Agnimonhan, Léon A. Ahoussi, Bienvenu Glinma, Justin M. Kohoudé, Fernand A. Gbaguidi, Salomé D. S. Kpoviessi, Jacques Poupaert and Georges C. Accrombessi
  
  The Willgerodt-Kindler (WK) reaction of is one of most synthesis methods used to access the thioamides. The known to thioamides have made this reaction more attractive in catalytic synthesis methods. Heterogeneous catalysis acid with the montmorillonite K-10 applied to this reaction under activation microwave for the synthesis of phenyl (morpholino) methanethiones derivatives shows that the mixture (aldehyde, sulfur, morpholine and K-10) is not only appropriate, but optimizes the reaction. This solid catalyst was easily separated from the reaction mixture and was recycled at least twice (02) without any loss of activity. Operational simplicity, short reaction times, excellent yields and benign environmental conditions are other advantages of this protocol, thus respecting the principles of green chemistry. Among the thioamides synthesized, 4-(morpholine-4-carbonothioyl)benzoic acid (h.. View More»
  DOI: 10.4172/2161-0401.1000180

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