Journal of Proteomics & Bioinformatics
Open Access

Hyeon S Son

Publications

• Research Article
  Protein Fold Classification with Backbone Torsional Characters Using Multi-Class Linear Discriminant Analysis
  Author(s): Se-Eun Bae, Sunghoon Jung, Insung Ahn and Hyeon S Son Se-Eun Bae, Sunghoon Jung, Insung Ahn and Hyeon S Son
  
  The classification of the structures of proteins provides preliminary information for the further detailed theoretical analyses. Classified information of protein folds might be utilized for the structural alignment while fold class prediction might help ab inito prediction of protein structures. Here, prediction of structural fold class of proteins with torsion angle based secondary structure profile library and multi-class linear discriminant analysis was performed. All-versus-all method was utilized to circumvent the problem of data imbalance of one-versus-others approach. From nonredundant structure files, a tripeptide secondary structure profile library was constructed and used to calculate the probable secondary structure content of protein folds. The mean and covariance matrices of the reference classes of the training set were derived using this library. Based on this informat.. View More»
  DOI: 10.4172/jpb.1000273

  Abstract PDF

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