Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Research Article
Immunological Profile of HIV-Infected Patients with Tuberculosis Associated-Immune Reconstitution Inflammatory Syndrome: A Systematic Review
Author(s): Luana Leandro Gois, Yuri Reis Casal, Igor Libório Augusto Pedreira, Antonio Carlos Bandeira, Roberto Badaró, Maria Fernanda Rios GrassiLuana Leandro Gois, Yuri Reis Casal, Igor Libório Augusto Pedreira, Antonio Carlos Bandeira, Roberto Badaró, Maria Fernanda Rios Grassi
Objective: This study systematically reviews the literature that describes the immunological profile associated with the development of tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) in HIVinfected individuals. Methods: Between the primary and secondary searches, a total of 20 articles were selected for the final analysis. Results: The results obtained herein indicated that TB-IRIS was associated with the recovery of Mtb-specific immune response, demonstrated by an increased frequency of specific IFN-g-producing cells and specific multifunctional T-lymphocytes (TNF and IFN-γ-producing). In addition, an increased production of inflammatory cytokines and chemokines was found in TB-IRIS patients compared to non-IRIS individuals. Conclusion: .. View More»
DOI:
10.4172/2155-9899.1000337