Journal of Nutrition & Food Sciences
Open Access

Ikuo Kimura

Publications

• Research Article
  An Enteral Formula Containing Fermented Milk Products and Prebiotics Promotes Glucagon-Like Peptide-1 Secretion via Short Chain Fatty Acid Signaling
  Author(s): Hisae Kume, Keiko Okazaki, Naoko Yamamoto, Yusuke Omae, Kinya Ashida, Takeshi Takahashi and Ikuo Kimura Hisae Kume, Keiko Okazaki, Naoko Yamamoto, Yusuke Omae, Kinya Ashida, Takeshi Takahashi and Ikuo Kimura
  
  An enteral formula containing fermented milk products and prebiotics (prebiotic formula, PF) is known to promote the proliferation of Bifidobacterium and the production of short-chain fatty acids (SCFAs) in humans and rats. We studied the effect of PF on the secretion of glucagon-like peptide-1 (GLP-1) and the involvement of SCFAs in this process, using the knockout (KO) mice for the SCFA receptors G protein-coupled receptor 41 (GPR41) and G protein-coupled receptor 43 (GPR43). Wild type (WT) or KO mice were fed either a standard formula (SF) or PF for two weeks, and then were orally administered either PF or SF after overnight fasting and dissected after 0, 30, 60, and 240 minutes. Blood GLP-1 and glucose levels were measured (Experiment 1). Alternatively, mice fed SF or PF for two weeks were dissected after four hours of fasting, and their blood GLP-1 and cecal SCFAs levels.. View More»
  DOI: 10.4172/2155-9600.1000662

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