Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Ildikó Molnár
Immunoendocrinology and Osteoporosis Centre, EndoMed,
Bem tér 18/C., H-4026 Debrecen
Hungary
Research Article
Anti-eye Muscle IgG and IgM Antibodies are Associated with Eye Muscle Type 2 Deiodinase Activities in Hyperthyroid Graves’ Ophthalmopathy
Author(s): Ildiko Molnar and Eva Somogyine-Vari
Ildiko Molnar and Eva Somogyine-Vari
Objective: Antibodies to eye muscle tissue are demonstrated in hyperthyroid Graves’ disease but their pathognomonic roles have not been clarified yet. We suggest that type 2 deiodinase (DIO2) enzyme can be a target between orbital and thyroid diseases in hyperthyroid Graves’ ophthalmopathy. In this study, the relationship between anti-eye muscle membrane (EyeM) and cytosol (EyeC) IgG, IgA and IgM antibodies and eye muscle DIO2 activity was investigated in hyperthyroid Graves’ disease.
Methods: Thirty-two patients with hyperthyroid Graves’ disease (20 had ophthalmopathy), mean age 36 ± 13 years, 27 females and 5 males formed the patient group. Thyroid hormone levels were measured with chemiluminescence immunoassay, antithyroid antibody and anti-eye muscle antibody levels with enzyme-linked immunosorbent assay, but .. View More»
DOI:
10.4172/2155-9899.1000463