Mycobacterial Diseases
Open Access

Innocent Uwimana

Publications

• Research Article
  Performance Assessment of the GenoType®MTBDRplus Assay for Rapid Detection of Multidrug-Resistant Tuberculosis among Clinical Isolates in Low Tuberculosis Burden Setting
  Author(s): Innocent Uwimana, Eliane Kamanzi, Elyse Mukamukwiye, Etienne Kayigi, Aniceth Rucogoza, Emil Ivan Mwikarago, Francine Birungi, Joseph Ntaganira and Claude Muvunyi Innocent Uwimana, Eliane Kamanzi, Elyse Mukamukwiye, Etienne Kayigi, Aniceth Rucogoza, Emil Ivan Mwikarago, Francine Birungi, Joseph Ntaganira and Claude Muvunyi
  
  Introduction: New molecular assays for rapid Multidrug-Resistant Tuberculosis (MDR-TB) detection continue to be developed. Rwanda has recently introduced the line probe assay for early TB and MDR-TB diagnosis. We aimed to assess the performance of GenoType® MTBDRplus test before its implementation in the routine testing. Methods: Sputum samples from suspected MDR-TB patients received and processed at Rwanda National Reference Laboratory from 2010-2012 were included in this study. The performance of Genotype® MTBDRplus assay was evaluated versus the standard phenotypic conventional Drug Susceptibility Testing (DST) on Lowenstein Jensen. Sensitivity, specificity and predictive values (positive and negative) were calculated. Statistical analyses were performed using Epi Info version 3.5.3. P-values were derived from χ2 tests applyin.. View More»
  DOI: 10.4172/2161-1068.1000247

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