Journal of Clinical and Cellular Immunology
Open Access

Irene Blanco

Publications

• Research Article
  The Association between Anti-Nuclear Antibodies and Obesity is Likely Mediated by Abdominal Adiposity and Systemic Inflammation
  Author(s): Irene Blanco, Monalyn Labitigan and Matthew K. Abramowitz Irene Blanco, Monalyn Labitigan and Matthew K. Abramowitz
  
  Background: Obesity and abdominal adiposity have been associated with inflammation as have the presence of anti-nuclear antibodies (ANAs). It was recently reported that there is a decreased likelihood of ANAs in the obese general population. To examine this relationship we used data from adult participants in the National Health and Nutrition and Examination Survey 1999-2004. Methods: Participants were excluded if they reported a history of arthritis other than osteoarthritis, thyroid or liver disease, or steroid use so as to rule out a history of possible prior autoimmune disease. We strictly defined a positive ANA as a titer ≥ 1:160. Overweight and obesity were classified using traditional BMI criteria. High and low C-reactive protein (CRP) were defined using the 75th percentile cutpoint as ≥0.42 and <0.42 mg/dL, respectively. Dual-e.. View More»
  DOI: 10.4172/2155-9899.1000513

  Abstract PDF

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