Journal of Proteomics & Bioinformatics
Open Access

Irini Doytchinova

Publications

• Review Article
  Immunogenicity Prediction by VaxiJen: A Ten Year Overview
  Author(s): Nevena Zaharieva, Ivan Dimitrov, Darren R Flower and Irini Doytchinova Nevena Zaharieva, Ivan Dimitrov, Darren R Flower and Irini Doytchinova
  
  Vaccination stands alone as an unparalleled medical intervention able to save human lives numbering hundreds of millions. Modern licensed vaccines are either whole organism based or based on single proteins, together with carbohydrate epitope-based vaccines. Single protein or so-called subunit vaccines are prime targets for vaccine design and reverse vaccinology. Immunoinformatics is a branch of bioinformatics focusing on immunology and vaccinology, which includes database compilation, data mining, and epitope prediction. Immunoinformatics can aid in the discovery of subunit vaccines through algorithms for immunogenicity prediction. VaxiJen is the first and, ostensibly, the only widely-used method for distinguishing between immunogens and non-immunogens among proteins of bacterial, viral, parasite, fungal and tumour origin. In this review, we chart the applications of VaxiJen, placing.. View More»
  DOI: 10.4172/jpb.1000454

  Abstract PDF

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