Lupus: Open Access
Open Access
ISSN: 2684-1630
+44 1300 500008
ISSN: 2684-1630
+44 1300 500008
Irun R. Cohen
Emeritus, The Weizmann Institute of Science Rehovot 76100,
Israel
Review Article
Antigen-Microarray Profiling of Antibodies in SLE: A Personal View ofTranslation from Basic Science to the Clinic
Author(s): Irun R. CohenIrun R. Cohen
In October of 2015, the startup company ImmunArray announced the launch of a microarray platform – the iChip® – to profile repertoires of serum antibodies and autoantibodies. The first iChip® product – the SLE-key® RuleOut test – is designed to help the physician rule out a diagnosis of systemic lupus erythematosus (SLE) in suspected patients. The aim of this review is threefold: the first aim is to describe how basic observations and a philosophical notion led me to undertake the development of what has turned out to be a clinically useful aid in dealing with complex diseases; the second aim is to describe the role of a company in overcoming the technological and informatics challenges involved in translating basic research into patient welfare; the third aim is to discuss why SLE, like other complex medical problem.. View More»
DOI:
10.35248/2684-1630.16.1.118