Journal of Clinical and Experimental Ophthalmology
Open Access
ISSN: 2155-9570
ISSN: 2155-9570
Research Article
Effects of Nutritional Supplement with α-Lipoic Acid in Patients with Recurrent Pterygium
Author(s): Jorge Guillermo Hurtado Godinez, Leonel Garcia Benavides, Sara Pascoe Gonzalez, Ivan Isidro Hernandez Cañaveral, Francisco Javier Galvez Gastelum and Irinea Yañez SanchezJorge Guillermo Hurtado Godinez, Leonel Garcia Benavides, Sara Pascoe Gonzalez, Ivan Isidro Hernandez Cañaveral, Francisco Javier Galvez Gastelum and Irinea Yañez Sanchez
Background: Pterygium is an ocular disease characterized by fibro-proliferative disarray of the corneal surface. Control of oxidative stress with effective antioxidant supplementation, like α-lipoic acid, could prevent recurrence following surgical resection.Materials and methods: This study was a randomized placebo-controlled, double-blind trial. Seventy patients with recurrent pterygium participated. Oral therapy with α-lipoic acid or placebo was administered. Pterygium tissue was collected for histological and immunohistochemical analysis.Results: Pterygium recurrence was similar in both groups. A significant increment of fibroelastic tissue was observed in the placebo compared with the α-lipoic acid group. Number and caliber of blood vessels, extracellular matrix content and presence of inflammatory infi.. View More»
DOI:
10.4172/2155-9570.1000338