Journal of Clinical and Cellular Immunology
Open Access

Ivana Cacciatore

Publications

• Research Article
  Cyclo (His-Pro) Protects SOD1G93A Microglial Cells from Paraquat–Induced Toxicity
  Author(s): Silvia Grottelli, Ilaria Bellezza, Giulio Morozzi, Matthew J Peirce, Cristina Marchetti, Ivana Cacciatore, Egidia Costanzi  and Alba MinelliSilvia Grottelli, Ilaria Bellezza, Giulio Morozzi, Matthew J Peirce, Cristina Marchetti, Ivana Cacciatore, Egidia Costanzi  and Alba Minelli
  
  Cyclo (His-Pro), an endogenous cyclic dipeptide produced by the cleavage of the hypothalamic thyrotropin releasing hormone, crosses the blood brain barrier and improves recovery in models of traumatic injury to the brain and LPS-induced neuroinflammation. The protective effects are sustained by the ability of the cyclic dipeptide to interfere with the Nrf2–NF-κB signalling systems, the former governing the antioxidant and the latter the proinflammatory cellular response. Amyotrophic lateral sclerosis is a fatal disease which affects motor neurons and causes death of the patient from respiratory failure within a few years following diagnosis. Most patients suffer from sporadic amyotrophic lateral sclerosis, but about 5–10% of all amyotrophic lateral sclerosis cases can be attributed to familial forms, which are caused by mutations in the gene encoding for superoxide di.. View More»
  DOI: 10.4172/2155-9899.1000287

  Abstract PDF

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