Clinical & Experimental Cardiology
Open Access

Jacek Jawien

Publications

• Review Article
  Mouse Experimental Models of Atherosclerosis in Pharmacology
  Author(s): Jacek JawienJacek Jawien
  
  The mouse has become an excellent model for experimental atherosclerosis research. Until 1992, the diet - induced atherosclerosis mouse model has been used effectively, but the lesions tended to be small and were limited to early fatty-streak stage. This model was also criticized because of the toxicity and inflammatory responses due to the diet. In 1992 the first line of gene targeted animal models, namely apolipoprotein E - knockout mice was developed. Of the genetically engineered models, the apoE - deficient model is the only one that develops extensive atherosclerotic lesions on a chow diet. It is also the model in which the lesions have been characterized most thoroughly. The lesions develop into fibrous plaques; however, there is no evidence that plaque rupture occurs in this model. The LDL receptor - deficient model has elevated LDL levels, but no .. View More»
  DOI: 10.4172/2155-9880.S1-001

  Abstract PDF

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