Advanced Techniques in Biology & Medicine
Open Access
ISSN: 2379-1764
ISSN: 2379-1764
Jae Hoon Kim
College of Applied Life Science SARI,
102 Jejudaehak-ro, Jeju-si Jeju-do 690-756
Republic of Korea
Mini Review
Contribution of DUSP28 to Regulation of Mucins in Human Pancreatic Cancer Cells
Author(s): Jungwhoi Lee and Jae Hoon Kim
Jungwhoi Lee and Jae Hoon Kim
Pancreatic cancer remains one of the most deadly cancers, and once diagnosed, the prognosis for patient survival is poor. Patient outcomes have not been improved despite considerable and continuous efforts. We have suggested that dual-specificity phosphatase 28 (DUSP28) is a potential anti-cancer target to inhibit malignant pancreatic cancers. In this context, atypical DUSP28 can affect the regulation of mucins such as mucin5B (MUC5B) and mucin16 (MUC16). To investigate this correlation, we analysed mRNA levels of DUSP28 and mucins using the Gene Expression Omnibus public microarray database in pancreatic cancer, which indicated higher DUSP28, MUC1, MUC4, MUC5B, MUC16 and MUC20 mRNA levels in pancreatic cancers compared with normal pancreas tissue. In addition, DUSP28 expression in human pancreatic cancers correlated positively with those of MUC1, MUC4, MUC5B, MUC16 and MUC20. In cont.. View More»
DOI:
10.4172/2379-1764.1000232