Clinical & Experimental Cardiology
Open Access

Jamie R. Mitchell

Publications

• Case Report
  Left Ventricular Preload Determines Systolic Pressure Variation during Mechanical Ventilation in Acute Lung Injury
  Author(s): Jamie R. Mitchell, Christopher J. Doig, William A. Whitelaw, John V. Tyberg and Israel Belenkie Jamie R. Mitchell, Christopher J. Doig, William A. Whitelaw, John V. Tyberg and Israel Belenkie
  
  Background: Systolic pressure variation (SPV) predicts responsiveness to volume loading during mechanical ventilation and may be related to changes in LV preload and the resultant changes in stroke volume (SV). We, therefore, tested the relations between LV preload, output and SPV in an acute lung injury (ALI) model during mechanical ventilation. Methods: ALI was created by oleic acidinfusion (0.07 ml/kg) in 8 anesthetized dogs. We measured LV, RV, aortic, left atrial (LA) and pericardial pressures, LV area (ALVED) and SV during mechanical ventilation with positive endexpiratory pressures (PEEP) of 0, 6, 12 and 18 cmH2O at LV end-diastolic pressures of 5, 12 and 18 mmHg. Results: Throughout these ranges of PEEPs and filling pressures, SPV was inversely related to LV preload [ALVED and tra.. View More»
  DOI: 10.4172/2155-9880.1000143

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