Medicinal & Aromatic Plants
Open Access
ISSN: 2167-0412
+44 1300 500008
ISSN: 2167-0412
+44 1300 500008
Jamila H El-Medany
Saudi Arabia
Research Article
Expanding the Therapeutic Utility of Curcumin: An Experimental Study on DMH-induced Colorectal Cancer
Author(s): Azza H El-Medany, Hanan H Hangar, Omnia A Nayel and Jamila H El-MedanyAzza H El-Medany, Hanan H Hangar, Omnia A Nayel and Jamila H El-Medany
search for drugs that can target cancer cell microenvironment in as much as being able to halt malignant cellular transformation, the natural dietary phytochemical curcumin was currently assessed in DMH-induced colorectal cancer rat model. The study enrolled 50 animals divided into a control group (n=10) and DMH-induced colorectal cancer control group (n=20) (20 mg/kg.-body weight for 28 weeks) versus curcumin-treated group (n=20) (160 mg/kg suspension daily oral for further 8 weeks). Treatment by curcumin succeeded to significantly decrease the percent of ACF and tended to normalize back the histological changes retrieved in adenomatous and stromal cells induced by DMH. The drug also significantly elevated GSH and significantly reduced most of the accompanying biochemical elevations (namely MDA, TNF-α, TGF-β and COX2) observed in colonic carcinomatous tissue, induced by DM.. View More»
DOI:
10.4172/2167-0412.1000310