Journal of Proteomics & Bioinformatics
Open Access

Jan Charles Biro

Publications

• Review Article
  Suggestion to Upgrade the Canonical Concept of Translation
  Author(s): Jan Charles BiroJan Charles Biro
  
  Background: This research was carried out to provide a summary of a series of bioinformatical observations between 2000 and 2014 concerning the structure of nucleic acids and codons, the interaction between codons and amino-acids and the general concept of translation. Methods: Public sequence and structure databases and established methods of bioinformatics resources were utilized during these studies. Results: These studies provided novel insights into the canonical concept of translation and suggest that: 1) codons have structure and the development and function of the 1st, 2nd, 3rd codon residues is different; 2) codon boundaries are physicochemically defined; 3) there is a stereo-chemical compatibility (fitting) between codons and coded amino acids; 4) codon redundancy in the Genetic Code (synonymous codons) provides folding (3D) information to protein syntheses, .. View More»
  DOI: 10.4172/jpb.1000311

  Abstract PDF

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