Journal of Hematology & Thromboembolic Diseases
Open Access

Jan Jacques Michiels

Publications

• Research Article
  Signs and Symptoms of Myeloproliferative Neoplasms (MPN), Quality of Life, Social Activity, Work Participation and the Impact of Fatigue in Dutch MPN Patients: A One Country Questionnaire Investigation of 497 MPN Patients
  Author(s): Michiels JJ Michiels JJ
  
  The main primary symptoms in 363 MPN patients subdivided in 123 ET, 190 PV and 50 MF patients were fatigue, night sweats, pruritis and bone pain. MPN diagnosis was based on symptoms in 56% (n = 203), detected by coincidence in 30% (n = 110) and based on complications in 14% (n = 49). The 497 MPN patients were on treatment with low dose aspirin in 70%, phlebotomy in 42% (mainly PV 91%), hydroxyurea in about 30% of ET, PV and MF, and pegylated interferon-alpha2a in 16% of ET and PV patients at time of evaluation. The MPN patients were limited in physical mobility in 10%, 14% and 24%, limited in the ability to exercise in 15%, 29% and 38% and social activity was restricted in 9%, 11% and 11% of ET, PV and MF patients respectively. Non-retired MPN patients experienced self-reported fatigue as the main reason for the inability to work full-time in 31% of ET, 40% of PV and 59% of MF patient.. View More»
  DOI: 10.4172/2329-8790.1000241

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