Journal of Leukemia
Open Access

Jayaraman Muthukumaran

Publications

• Research Article
  Genotype Distribution of Dihydrofolatereductase Variants and their Role in Disease Susceptibility to Acute Lymphoblastic Leukemia in Indian Population: An Experimental and Computational Analysis
  Author(s): Sunitha Kodidela, Suresh Chandra Pradhan, Jayaraman Muthukumaran, Biswajit Dubashi, Teresa Santos-Silva and Debdatta Basu Sunitha Kodidela, Suresh Chandra Pradhan, Jayaraman Muthukumaran, Biswajit Dubashi, Teresa Santos-Silva and Debdatta Basu
  
  Objectives: To establish the allele and genotype frequencies of dihydrofolate reductase (DHFR) -317A>G and -680C>A variants in Indian population, to find the association of these variants with the risk of acute lymphoblastic leukemia (ALL) and to analyze the effects of non-synonymous SNPs (nsSNPs) and 3’untranslated region (3’UTR)variants of DHFR gene on its structure and function using in-silico tools. Methods: A total of 235 unrelated healthy volunteers (controls) and 127 ALL patients (cases) were recruited for the study. DNA was extracted from peripheral leucocytes. Genotyping of DHFR polymorphisms was done by realtime PCR. We investigated the deleterious effect of nsSNPs and variants in 3’UTR of DHFR gene through computational platforms. Results: In the present study, the frequency of DHFR -31.. View More»
  DOI: 10.4172/2329-6917.1000209

  Abstract PDF

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