Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Jean G Sathish
Department of Molecular & Clinical Pharmacology and the MRC Centre for Drug Safety Science,
Sherrington Buildings, Ashton Street, Liverpool L69 3GE
United Kingdom
Review Article
T Cell Co-inhibitory Receptors-Functions and Signalling Mechanisms
Author(s): Thilipan Thaventhiran, Swaminathan Sethu, Han Xian Aw Yeang, Laith Al-Huseini, Junnat Hamdam and Jean G SathishThilipan Thaventhiran, Swaminathan Sethu, Han Xian Aw Yeang, Laith Al-Huseini, Junnat Hamdam and Jean G Sathish
T cell activation is a central event in the adaptive immune response and essentially begins with the recognition of an antigenic peptide in the context of a major histocompatibility complex (MHC) on an antigen-presenting cell by the T cell receptor (TCR). The process of T cell activation consists of an orchestration of various functional modules such as actin polymerization, cell surface receptor patterning, calcium fluxing, immunological synapse formation, enhanced adhesion and gene transcription. These modules are mediated by a number of signalling proteins through inducible phosphorylation, enzyme activation and protein-protein & protein-lipid interactions. This complex and dynamic interplay of signalling events governs the decisions the T cell makes in terms of gene expression, proliferation, differentiation, survival and migration. These outcomes are influenced by the magnitu.. View More»
DOI:
10.4172/2155-9899.S12-004