Journal of Clinical Toxicology
Open Access

Jean-Marc Thouret

Publications

• Case Report
  Acute Exenatide Overdose
  Author(s): Christine Payen, Jean-Marc Thouret, Jacques Descotes and Thierry VialChristine Payen, Jean-Marc Thouret, Jacques Descotes and Thierry Vial
  
  Exenatide, a glucagon-like peptide-1 (GPL-1) receptor agonist, was quite recently approved as adjunctive therapy to improve glycemia control in type 2 diabetes patients. There is very limited information on overdose consequences. We report 3 cases of exenatide overdose involving 2 suicidal self-injections associated with psychotropic intake and one medication error. Two patients rapidly experienced gastro-intestinal symptoms and none of them presented severe hypoglycemia, which is in accordance with the known biological activity of GLP-1 that acts in a glucose-dependent manner and does not inhibit glucagon release in case of hypoglycemia. Interestingly one patient, who ingested large amounts of psychotropic drugs together with self-injection of a large dose (600 μg) of exenatide, presented unexpected delayed onset of central nervous system (CNS) symptoms whereas no hypoglycemia was.. View More»
  DOI: 10.4172/2161-0495.1000214

  Abstract PDF

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